Revised 8/2022

CHM 246 - Organic Chemistry II Laboratory (2 CR.)

Course Description

Introduces various methods and procedures used in present day organic laboratories. Covers the general techniques, organic synthesis, and the use of common spectroscopic instrumentation; synthesizing a variety of compounds; and analyzing the products through physical properties and spectroscopy. Part II of II. Lecture 1 contact hour. Lab 3 contact hours. Total 4 contact hours.

General Course Purpose

Explores the physical properties and reactivity of organic compounds including common methods of separation, purification, and instrumental analysis. (Continued from CHM 245)

Course Prerequisites/Corequisites

Prerequisite: CHM 245; Corequisite: CHM 242.

Course Objectives

Upon completing the course, the student will be able to:

Continued: Safety in the Organic Laboratory

  • Use proper procedures and regulations for safe handling and use of chemicals in the organic chemistry laboratory
Continued: Lab notebook
  • Maintain a lab notebook and demonstrate proper recording, organization, and interpretation of scientific data
Application of Laboratory techniques from CHM 245
  • Formulate and perform the laboratory synthesis, purification, and characterization of the organic compounds studied; applying techniques covered in CHM 245.
1H and 13C NMR Spectroscopy
  • Interpret spectra and identify compounds
Synthesis and analysis
  • Preparation and analysis of a variety of organic compounds.
  • Perform theoretical yield, percent yield, and percent recovery calculations.
  • Potential reactions to be studied include: Grignard reaction, EAS reaction, Fischer esterification, aldol condensation, polymers
  • Additional lab experiments that could be included: Synthesis of biodiesel,
  • Diels-Alder, oxidation/reduction reactions, free radical halogenation, synthesis of aspirin, hydroboration-oxidation of alkenes
Mechanism
  • Propose mechanisms for all reactions.
Theoretical understanding
  • Explain the theoretical basis of all techniques and state reasons for use of specific reagents.

Major Topics to Be Included

  • Continued: Safety in the Organic Laboratory
  • Continued: Lab notebook
  • Application of Laboratory techniques from CHM 245
  • 1H and 13C NMR Spectroscopy
  • Synthesis and analysis
  • Mechanism
  • Theoretical understanding