Special Organic Chemistry Lab II
CHM 246 - Summer 2008
Mon-Tue-Thu 3:00 pm - 6:00 pm, AA429C

Instructor: Dana Horoszewski, Ph.D.
Email: dhoroszewski@nvcc.edu
Phone: 703-845-6002
Office Hours: M 11:00 - 12:00 (Office), T 10:30 - 11:50 (Tutoring Room - AA431)

TEXT

The linked webpages and douments in the table below are your text book for this course. If you want to supplement the information in the web pages, I reccomend The Organic Chem Lab Survival Manual: A Student's Guide to Techniques by James Zubrick (older editions available online for cheap) or Experimental Organic Chemistry: A Miniscale and Microscale Approach, by Gilbert & Martin (on reserve in the library)

OTHER REQUIRED MATERIALS
1) Splash-proof laboratory goggles. Splash-proof googgles, like the ones sold at the bookstore, are the only acceptable type of googgles. If you bring non-splash-proof googles to lab, you will not be allowed to participate.
2) Bound laboratory notebook - no spiral bound, no loose leaf, you need a marble notebook or something similar.
3) Proper attire – feet must be completely covered, no sandals, no crocs, you should also be covered from shoulders to knees.
Link to all safety procedures

TENTATIVE LAB SCHEDULE
Date Lab Activity Lab Manual Relevant Links
6/24 Check-In/Safety and Orientation  
6/26 Computer Unknown comp_unknown  
6/30 Computer Unknown Test    
7/1 Wet Lab Unknown wet_unknown

carboxylic acid table
phenol table

7/3 Wet Lab Unknown  
7/7 Begin Diels-Alder Cycloaddition dielsalder  
7/8 Oxidation of Cyclohexanol oxidation  
7/10 Grignard Reaction grignard  
7/14

Finish Diels-Alder
Acid/Base Strength of Organics

acid_base  
7/15 Self Assembled Monolayers hydrophobic
7/17 Synthesis of Apirin aspirin
7/21 Preparation of an Ester
Begin Aldol Condensation

ester

aldol

7/23 Finish Aldol Condensation
7/24 Finish up Labs/Check out
7/28 No Lab
7/29 No Lab
 
 

SOURCES OF INFORMATION

This is a short list of where you may find the information required for this course.  These are references where you might find densities, boiling points etc. for this lab:

1) Aldrich Chemical Catalog:This has the advantage of having many compounds in it, and listing them in alphabetical order.Watch out for grades of chemicals (Tech. 90% or ACS reagent grade 99.998%), and deuteration – addition of one or more deuterium atoms to replace hydrogen.The latter appears as, for example, “acetone-d 6”, or “ethyl acetate – d 3”.We will usually not use technical grade chemicals, and we never use isotopically substituted ones.

2) The Merck Index: Less comprehensive that Aldrich.Limited to chemicals that are biomedical in use.However, it is very readable.

3) The CRC Handbook of Physics and Chemistry (as well as other CRC books): This is an exhaustive compilation of organic compounds.  However, it helps a lot if you have a good grasp of organic nomenclature.For example, bromobenzene is “benzene, bromo”; and “n-butyl acetate” is “Acetic acid, n-butyl ester”.

4) Beilstein, the Dictionary of Chemistry, the Dictionary of Organic Compounds, and others are useful to some, but to me are either too hard to use, or incomplete.The ACS index is just as good and hard to use.

5) “On Line Sources” Yes, they are out there.But be specific on your URL citations, and be sure it is a reliable source.