OBJECTIVES FOR BIO 141
HUMAN ANATOMY AND PHYSIOLOGY I
NORTHERN VIRGINIA COMMUNITY COLLEGE
ANNANDALE CAMPUS

Choose a Topic
    An Introduction to Human Anatomy and Physiology
    The Chemical Basis of Life I
    The Chemical Basis of Life II
    Cell
    Cell Metabolism: Enzymes and Energy Releasing Metabolic Reactions
    Tissues
    Skin and Integumentary System
    Skeletal System
    Muscular System
    Respiratory System
    Blood
    Cardiovascular System

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Objectives-Chapter 1, An Introduction to Human Anatomy and Physiology
1. Define or recognize a definition of:
    anatomy, physiology, metabolism, organism, homeostasis, tissue, organ, organ system = system

2. List or recognize the ten characteristics of life.

3. Define, list and arrange in sequence the levels of organization of matter.

4. Describe a negative feedback system and contrast it with a positive feedback system.

5. Distinguish between the axial and appendicular portions of the human body.

6. List by name and locate on a diagram the principal body cavities and their major organs.
    dorsal body cavity, ventral body cavity, cranial cavity, abdominolpelvic cavity, spinal (vertebral cavity),
    thoracic (chest) cavity,  two pleural cavities, mediastinum,  pericardial cavity

7. Identify or describe each of the following:
    diaphragm, viscera, anatomical position

8. Distinguish between and give the location of the following serous membranes:
    parietal and visceral pleura
    parietal and visceral pericardia
    parietal and visceral peritonea

9. List the principal organ-systems of the human body and be able to associate representative organs and functions with them.

10. Define and use the directional terms associated with relative position
      superior - inferior, anterior - posterior, dorsal - ventral,  medial - lateral,  ipsilateral-contralateral,
      proximal - distal, superficial - deep

11. Identify on a diagram and recognize a written description of each of the following body sections:
      sagittal, mid-sagittal, transverse (= horizontal), frontal (= coronal)

Transverse Section of the Thorax
12. Distinguish between cross, longitudinal and oblique sections.

13. List and locate on a diagram the nine abdominolpelvic regions.

14. Name and locate the four quadrants of the abdominolpelvic cavity on a  diagram.

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Objectives-Chapter 2, The Chemical Basis of Life-I
1. Define:
    matter, element, symbol, atom, isotope, compound, formula,  molecule, ion, atomic number, atomic weight,
    chemical bond, chemical equation, electrolyte

2. Associate the following symbols with the elements they represent:
    C,  H,  O,  N,  P,  S,  Na,  Ca,  Mg,  Cl,  K,  Fe,  I,  Co,  Cu

3. Describe the following parts of an atom:
    electron, proton, neutron

4. Tell how many protons, neutrons and electrons make up a simple atom if given the atomic number and atomic weight.

5. Identify an isotope of an element if given the atomic number and atomic weight of one form of the element.

6. Locate the symbol, atomic number and atomic weight for an element on a periodic chart of the elements.

7. Identify an ion if provided several alternatives on paper.

8. Recognize examples of and distinguish between:
    ionic bonds
    polar and nonpolar covalent bonds
    single, double and triple covalent bonds
    hydrogen bonds

9. Recognize the following basic types of chemical reactions:
    synthesis, decomposition, exchange

10. Distinguish between inorganic and organic compounds and give examples of each type.

11. Distinguish between:
      acids, bases and buffers
      weak and strong acids and bases
      solution, solute and solvent

12. Define pH and identify the neutral point, the acid range and the basic or alkaline range on a pH scale.

13. Describe and/or answer questions related to the carbonic acid - bicarbonate buffer system.

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Objectives-Chapter 2, The Chemical Basis of Life-II
 1. Describe the importance of carbon to the structure of organic compounds.

 2.  List the four main classes of organic compounds and the main elements that compose them.

 3.  List: a.  Two functions each for carbohydrates, lipids and  nucleic acids
             b.  Five functions of proteins

 4.  Identify the following functional groups:
      alcohol(or hydroxyl),  aldehyde, carboxyl,  ketone, amino,   phosphate

 5.  Place each carbohydrate listed below in one of the following  groups - monosaccharides, disaccharides, polysaccharides:
      glucose,   lactose,  starch,  fructose,   sucrose,  glycogen,  galactose,   maltose,  cellulose,  ribose, deoxyribose

 6.  Recognize:
      a condensation reaction (dehydration synthesis)
      a hydrolysis reaction
      glycerol
      a fatty acid
      a fat
      a phospholipid
      a steroid
      an amino acid
      a peptide linkage (peptide bond)
      a dipeptide or a polypeptide

7. Distinguish between a saturated and an unsaturated fatty  acid.

 8. Identify and distinguish between the levels of protein structure.

 9.  Distinguish between DNA and RNA.

10.  Identify:
       ATP, nucleotide, isomer, denature

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Objectives-Chapter 3, The Cell

1. Locate each of the following eukaryotic cell parts or organelles on a diagram and/or associate each with a written
    description:
    cell membrane, cilium, flagellum, endoplasmic reticulum (smooth and rough), microfilaments, microtubules,
    ribosomes, Golgi apparatus, mitochondrion, centrioles, lysosome, peroxisome, nucleus, chromatin, chromosomes,
    genes, nuclear envelope, pores, nucleolus

2. Distinguish between tight junctions, desmosomes and gap junctions.

3. Outline the cycle of growth and nuclear division of a typical eukaryotic cell.

4. List in order the phases of mitosis beginning with prophase and associate each with a written description.


Stages of Cell Division
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5. Discuss the significance of mitotic cell division.

6. Distinguish between cytokinesis and the nuclear events of mitosis.

7. Define or identify:
    cancer, spindle, chromatid, astral rays, cell differentiation, cleavage furrow, microvilli, protoplast, cytoplast,
    hemolysis, plasmolysis, protoplasm, cytoplasm, potential energy, kinetic energy, solute, solvent, solution,
    phagocyte, concentration, concentration gradient, protein carrier (permease)

8.  Distinguish between an impermeable, semipermeable and selectively permeable (differentially permeable) membrane.

9.  Distinguish between a solution (i.e., salt water), a colloidal suspension (i.e., milk), and a course suspension (i.e., soil water).

10. Describe the fluid mosaic model of the plasma (cell) membrane and list at least three functions of membrane proteins.

11. Distinguish between the following forms of movement across membranes:
      passive processes, active processes, simple diffusion, active transport, facilitated diffusion, phagocytosis,
      filtration, pinocytosis, dialysis, exocytosis, endocytosis

12. Describe what would happen to a red blood cell placed in:
      a.  a hypertonic solution, b.  an isotonic solution, c.  a hypotonic solution

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Objectives–Chapter 4, Cellular Metabolism: Enzymes and Energy Yielding Metabolic Pathways
1. Define what an enzyme is and describe at least five characteristics of enzymes.

2. Recognize the summary reaction for:
    a.  aerobic respiration,  b.  alcoholic fermentation,  c.  lactic acid fermentation

3. Describe the energy yield (# of ATP's formed) from glucose in:
    a.  aerobic respiration (glycolysis, connecting pathway, citric acid cycle, electron transport system)
    b.  alcoholic fermentation
    c.  lactic acid fermentation

4. Relate DNA and enzymes to metabolic pathways.

5. State how oxidized NAD (NAD+) is regenerated for glycolysis in lactic acid fermentation.

6. State the function of O2 in an aerobic metabolism.

7. Identify two ways the rate of aerobic respiration is regulated by cells.

8. Tell how carbon monoxide and cyanide poisonings can result in death.

9. Contrast the following pairs of terms:
    anabolism - catabolism, oxidation -  reduction, aerobic - anaerobic

10. Define or identify:
      metabolism, metabolic pathway, coenzyme A, FAD, NAD, pyruvic acid, oxaloacetic acid, citric acid,
      catalyst, energy, kilocalorie, substrate level phosphorylation,  oxidative phosphorylation, activation energy,
      cytochrome, B-oxidation, deamination

11. Describe the chemiosmotic model proposed by Peter Mitchell in 1961 to explain the coupling of ATP synthesis to
      electron transport.

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Objectives–Chapter 5, Tissues
1. Contrast the characteristics and functions of epithelial, connective, muscle and nerve tissues.

2. Describe how epithelial tissues are classified.

Simple Cuboidal Epithelium
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3. Distinguish between exocrine and endocrine glands and classify exocrine glands according to:
    a. structure - unicellular or multicellular; tubular or acinar (= alveolar)
    b. function - holocrine, merocrine or apocrine

4. Describe or recognize a description of the following connective tissues:
    a. areolar = loose fibrous
    b. dense fibrous = white
    c. elastic
    d. reticular
    e. hyaline cartilage
    f. spongy bone - trabeculae and red marrow
    g. compact bone - Haversian system (= osteon)
    h. adipose (fat) tissue
    i  blood - erythrocytes, leucocytes, platelets and plasma

5. Identify the following cell types found in connective tissue:
    fibroblast, macrophage (= histiocyte), mast cell, plasma cell, fat cell.

6. Contrast smooth, skeletal and cardiac muscle.

7. Describe the structure of a typical multipolar neuron.

8. Define or identify:
    tissue, histology, tendon, ligament, goblet cell, lacuna (plural lacunae), canaliculus(plural canaliculi),
    collagen, intercalated disc, elastin, keratin

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Objectives–Chapter 6, The Skin and Integumentary System
1. Distinguish between mucous, serous, cutaneous and synovial membranes.

2. Describe the main functions of the skin.

3. Identify the two layers that compose skin.

Section of Skin Showing Epidermis, Dermis and
Subcutaneous Layer
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4. List from innermost to outermost the layers of the epidermis and describe their functions.

5. Contrast the structure and functions of derivatives of the epidermis including hair, sebaceous glands, sudoriferous glands
    and nails.

6. Define or identify:
    arector pili muscle
    dermal papilla(plural papillae) and hair papilla
    hair follicle
    keratinocyte, keratin and keratinization
    melanocyte and melanin pigment
    tyrosinase and albinism
    sebum
    perspiration (= sweat)
    blackhead
    subcutaneous layer

7. What steps can be taken to prevent the formation of bed sores (decubitus ulcers)?

8. Be able to label a diagram illustrating features of the skin and subcutaneous layer.

9. Describe the appearance of skin in a light complexioned individual in the following conditions/situations:
    albinism, blood well oxygenated, anemia, embarrassed or overheated, cyanosis, jaundice

10. Distinguish between first, second and third degree burns.

11. Compare the "rule of nines" and Lund and Browder charts" for use in burn size estimation.

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Objectives–Chapters 7-8, The Skeletal System
1. Know the bones that comprise the axial and appendicular skeletons.

2.   Contrast spongy (cancellous) and compact bone.

Cross Section of an Osteon (=Haversian System)
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3.   Distinguish between osteocytes, osteoblasts and osteoclasts.

4.   Describe the basic structure of a long bone including:
      epiphysis and diaphysis
      red and yellow marrow
      articular (hyaline) cartilage
      epiphyseal disk and epiphyseal line
      periosteum and endosteum
      medullary cavity
      spongy and compact bone

5.   Distinguish between red and yellow marrow.

6.   Identify six functions of bones.

7. Distinguish between intramembranous ossification and endochondral ossification.

8.   Describe the growth and development of a long bone including:
      primary and secondary ossification centers
      growth in length and growth in diameter

9. Describe the affect of each of the following on bone growth and development.
    vitamin D
    growth hormone = somatotropin
    thyroid hormone
    calcitonin
    parathyroid hormone
    estrogens as compared to androgens
    physical stress associated with exercise

10. Distinguish between the following systems of classifying joints:
      A.  Functional classification
            synarthroses
            amphiarthroses
            diarthroses
       B.  Structural classification
             fibrous (i.e., suture, syndesmosis)
             cartilaginous (i.e., synchondrosis, symphysis)
             synovial

11.  Identify six types of synovial joints.

12.  Define or identify:
       hematopoiesis = hemopoiesis, trabeculae, Haversian system = osteon, Volkmann's canal, hydroxyapatite,
       ligament, tendon, joint = articulation, bursa, hematoma

13. Be familiar with the following skeletal system diseases/disorders/problems.
      rickets                       pp. 204, 752
      osteomalacia              pp. 204, 752
      pituitary dwarf            pp. 204, 517
      pituitary giant              pp. 204, 517
      acromegaly                 pp. 204, 517
      fracture                       p.  206
      types of fractures        p.  206
      fracture repair             p.  206, 207
      osteoporosis               p.  210
      kyphosis                     p.  231
      scoliosis                      p.  231
      lordosis                       p.  231
      osteomyelitis                p.  248
      dislocation(luxation)     p.  292
      sprain                          p.  290
      bursitis                        p.  290
      arthritis                       pp. 290 - 292

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Objectives-Chapter 9, The Muscular System
1. Relate a:  muscle to a fasciculus
    fasciculus to a muscle fiber
    muscle fiber to a myofibril
    myofibril to a sarcomere
    myofibril to myofilaments (thick and thin)
Skeletal Muscle Fibers
©1996 Victor Eroschenko
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2. Define or identify:
    sarcolemma                        transverse tubule
    sarcoplasmic reticulum        motor unit
    endomysium                       motor neuron
    perimysium                         motor-end-plate
    epimysium                          actin
    fascia                                 troponin-tropomyosin
    acetylcholine                      myasthenia gravis
    Ca++                                 all-or-none-response (motor unit)
    cross bridge                       graded response (muscle)
    creatine phosphate             muscular hypertrophy
    lactic acid                          staircase effect = treppe
    threshold stimulus               myoglobin
    muscle tone (tonus)
    atrophy
    myosin

3. Identify the proteins comprising the thick and thin myofilaments.

4. Relate I bands, A band, H zone and Z lines to the arrangement of thick  and thin myofilaments in sarcomeres; which band
   doesn't change in width  during muscle contraction.

5. Describe the structure of the neuromuscular (myoneural) junction including:
    axon terminal,  synaptic vesicle, cholinesterase, synaptic cleft, motor-end-plate, neurotransmitter, receptor molecule

6. Describe the sequence of events in skeletal muscle excitation and contraction; state how excitation is coupled to contraction.

7. Describe the energy sources for muscle contraction and how the energy is used in skeletal muscle contraction and
    relaxation; define oxygen debt and explain how it arises.

8. Describe rigor mortis and identify its cause.

9. Define twitch and distinguish between isometric and isotonic twitches.

10. Relate tetany to summation and recruitment.

11. Describe why skeletal muscles must be fastened or anchored in opposing  pairs and identify prime mover, synergist and
      antagonist.

12. Contrast red (slow twitch) and white (fast twitch) fibers.

13. Summarize the effects of endurance training on skeletal muscles.

14. State why you think athletes generally perform better if they warm up by exercising lightly before a competitive event.

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Objectives-Chapter 19, Respiratory System
 1. Identify at least five functions of the respiratory system.

 2. Be able to trace the path of air flow from the atmosphere to the air sacs or alveoli identifying all major anatomical features.

 3. Identify the process involved in moving gases in each of the following situations:
     Atmosphere to lungs or vice versa
     Lung alveoli to blood or vice versa
     Transport in blood
     Blood to tissues/cells or vice versa
4. Describe the shape and number of cartilage rings in the
    trachea and explain why they are shaped in such a
    manner.

5. Distinguish between visceral and parietal pleura and
    locate the pleural cavity.

6. Describe the basic events of inspiration and expiration.

7. Identify the four different types of paranasal sinuses.

 8. Compare atmospheric, intrapleural and intraalveolar pressures during inspiration and expiration.

 9. Identify the three main types of tonsils located in the throat area.

10. Describe the role of hemoglobin in O2 transport in the blood and be able to interpret an oxygen-hemoglobin dissociation
      curve; compare it to an oxygen-myoglobin dissociation curve.

11. Explain how pH, PCO2, temperature and exercise affect the dissociation of oxygen from hemoglobin.

12. Describe the three means of CO2 transport in the blood and indicate which method is the most important; what is meant by
      the chloride shift?

13. Why is the PO2 160 mm Hg in the atmosphere and only about a 100 mm Hg in the alveoli?

14. Describe and/or distinguish between the different respiratory air volumes including:
      tidal volume                             vital capacity
      inspiratory reserve volume        residual volume
      expiratory reserve volume         total lung capacity

15. Define dead air space and distinguish between minute respiratory volume and alveolar ventilation rate.

16. Identify the location of the respiratory center.

17. Explain why a child who holds their breath will not die from lack of oxygen.

18. Explain why someone may pass out when they hyperventilate?  How is the same basic principle used by underwater
      divers?

19. Explain what the following receptors respond to and how they affect the rate and depth of breathing.  Is high PCO2 /H+ or
      PO2 more important in controlling normal breathing rate?
      chemoreceptors in the chemosensitive area of the medulla
      chemoreceptors in the carotid and aortic bodies
      stretch receptors in the lungs-Hering Breuer reflexes
      peripheral proprioceptors in muscles, ligaments and tendons

20. Be able to define or identify the following:
      epiglottis
      glottis
      respiratory membrane
      superior, middle and inferior nasal  conchae
      eupnea, apnea, dyspnea
      superior, middle and inferior meati  (singular meatus)
      tonsillectomy
      tracheostomy
      carbonic anhydrase
      hyperventilation
      spirometer
      surface tension

21. Be able to describe or identify the following disorders:
      rhinitis                      sudden infant death syndrome (SIDS)
      sinusitis                    hyaline membrane disease = respiratory
      laryngitis                  distress syndrome
      pharyngitis               tonsillitis
      bronchitis                deviated septum
      pleurisy                   cleft palate
      pneumonia              asthma
      pneumothorax         asphyxiation = suffocation
      atelectasis
      emphysema
      rales

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Objectives-Chapter 14, Blood
1. State how the cardiovascular system, lymphatic system, blood, interstitial fluid and lymph are interrelated.

2. Describe fluid exchange at capillaries and identify the two main driving forces.

3. Describe the composition of blood including formed elements and plasma.

4. Distinguish between and/or be able to recognize a definition of each cell  type/formed element in blood
    including erythrocyte(red blood cell), leukocyte(white blood cell) and platelet.

Blood Smear
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5. Distinguish between granulocytes(basophils, eosinophils and neutrophils) and agranulocytes(lymphocytes
    and monocytes).
6. Define anemia and distinguish between the following types of anemia.
    pernicious, aplastic, hypochromic, hemolytic, hemorrhagic

7. Give the range for a:
    a. normal red blood cell count
    b. normal total white blood cell count

8. Distinguish between:
    leukocytosis and leukopenia
    acute and chronic and myeloid and lymphoid leukemias
    total WBC count and differential WBC count

9. Identify the cell type that forms platelets (= thrombocytes)

10. Describe the three mechanisms involved in hemostasis including platelet plug formation, blood vessel spasms and blood
    coagulation.

11. Distinguish between the extrinsic and intrinsic blood clotting mechanisms and identify the final steps of both mechanisms.

12. Distinguish between thrombocytopenia and hemophilia.

13. List the four ABO blood groups and identify the agglutinogens (antigens) in the RBC membrane and the agglutinins
      (antibodies) in the plasma in each case.

Scanning image of red blood cells
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14. Define agglutination and be able to identify donor blood types which if  transfused into a recipient would not result in
      extensive agglutination.

15. Identify the Rh blood groups and describe the potential problems in Rh  incompatibility (mother is Rh negative and the
      fetus is Rh positive).

16. Describe crossmatching and blood typing using Anti-A, Anti-B and Anti-D antisera.

17. Define and/or identify:
      hematocrit                     fibrin                      jaundice                 hypercholesteremia and LDL
      hemopoiesis                  serum                     cyanosis                erythroblastosis fetalis
      stem cell                        macrophage           erythropoietin        kernicterus
      pus                                polycythemia         streptokinase
      heparin                          BUN test               tissue plasminogen activator (TPA)
      serotonin                       anticoagulant          reticuloendothelial tissue
      fibrinogen                      rhogam                  diapedesis

18. Identify six basic functions associated with the blood.

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Objectives-Chapter 15, Cardiovascular System
1. Distinguish between the pulmonary, systemic and coronary circuits.

2. Distinguish between a typical circuit and a portal circuit (i.e. renal portal circuit, hepatic portal circuit,
    hypothalamo-hypophyseal portal circuit).

3. Describe the coverings of the heart.

4. Identify the three layers that compose the wall of the heart including epicardium, myocardium and endocardium.

5. Be able to locate the atrioventricular and interventricular sulci.

6. Describe the skeleton of the heart and identify three functions it serves.

7. Trace a drop of blood through the heart listing the major blood vessels, chambers and heart valves in order starting with
    blood entering the right atrium.

8. Describe the blood supply to the heart wall.  What are anastomoses?

9. Define syncytium and identify the two syncytia of the heart.

10. Describe the cardiac conduction system including the sinoatrial (S-A) node, atrioventricular (A-V) node, atrioventricular
      (A-V) bundle (= bundle of His) and purkinje fibers.  Which structure serves as the pacemaker?  What is a bundle branch
      block?

11. Be able to interpret a normal electrocardiogram including P wave, QRS complex and T wave.

12. Describe a cardiac cycle and distinguish between systole and diastole.

13. Distinguish between parasympathetic and sympathetic regulation of the cardiac cycle.

14. Distinguish between the arterial and venous pressoreceptors and their affect on the cardioinhibitor and
      cardioaccelerator reflex centers in the medulla oblongata.

15. Relate the occurrence of a myocardial infarction to ischemia, ventricullar fibrillation, atherosclerosis,and
      a blood clot(a thrombus or an embolus).

16. Be able to distinguish between the following abnormal heart actions.
      tachycardia, bradycardia, ectopic beats,  fibrillation
      Which is more serious atrial or ventricular fibrillation?
      What is defibrillation?

17. Identify the three coats of an artery.

18. Distinguish between an artery, a capillary and a vein.

19. Be able to identify the following blood vessel disorders:
      atherosclerosis              varicose veins
      arteriosclerosis              hemorrhoids
      phlebitis

20. Define blood pressure and state how it changes with increasing distance from the ventricle.  How do arterial and venous
      blood pressures differ?

21. Identify four factors that aid the return of venous blood toward the atria.

22. Identify and describe five factors that influence arterial blood pressure including heart rate, stroke volume, peripheral
      resistance, blood volume and viscosity.

23. Describe how heart rate, stroke volume and cardiac output are related.

24. Describe the auscultatory method of blood pressure determination and distinguish between systolic and diastolic pressure.

25. State whether vasoconstriction and vasodilation increase or decrease peripheral resistance.  Does sympathetic stimulation
      of smooth muscle in arterioles cause vasoconstriction or vasodilation?

26. Identify the location of the greatest volume of blood in a normal distribution of blood volume (see Fig. 15.33).

27. Be able to describe the pressure changes in the left atrium and left ventricle during a cardiac cycle. When does the A-V
      valve close?  When does the aortic semilunar valve close?  (see Fig.  15.16 and related discussion).

28. Define and/or identify:
      chordae tendinae                    pericarditis
      papillary muscles                    endocarditis
      vasa vasorum                         Korotkoff's sounds
      blood brain barrier                 renin
      ascites                                   renin angiotensin mechanism
      plaque                                   atrial natriuretic factor
      stethoscope                           sphygmomanometer
      pulse                                      hypertension
      Starling's law of the heart        circle of Willis
      vasomotor center                   hyperkalemia and hypokalemia
      hypercalcemia and hypocalcemia

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