Material Safety Data
Section 1 - Chemical Product and Company
MSDS Name: Cyclohexanone
Catalog Numbers: AC111190000, AC111190010, AC111190025,
AC111190250, AC406095000, C550-4, O2109-1, O2109-4, O21094LC, O2109FB115,
O2109FB19, O2109FB200, O2109FB50, O2109POP19, O2109POP200, O2109POP50,
O2109POPB20, O2109POPB50, O2109RB200, O2109RB50, O2109SS115, O2109SS19,
O2109SS200, O2109SS28, O2109SS50
Synonyms: Ketohexamethylene; Pimelic
1 Reagent Lane
Lawn, NJ 07410
For information, call: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
Section 2 -
Composition, Information on Ingredients
Risk Phrases: 10 20
Section 3 - Hazards
Appearance: clear, colorless to pale yellow liquid. Flash Point: 44 deg C.
Harmful if absorbed through the skin. May cause central nervous system
depression. May be harmful if swallowed. May cause severe eye irritation and
possible injury. Warning! Flammable liquid
and vapor. Harmful if inhaled. Causes skin and respiratory tract irritation.
May cause liver and kidney damage.
Target Organs: Kidneys,
central nervous system, liver, respiratory system, eyes, skin.
Potential Health Effects
Eye: May result in corneal injury. Vapors may cause
eye irritation. Contact produces irritation, tearing, and burning pain.
Undiluted cyclohexanone placed in the eyes of rabbits caused marked ir ritation
and some corneal injury.
Skin: Causes skin irritation.
Harmful if absorbed through the skin. Not expected to cause an allergic skin
reaction. Cyclohexanone was not a sensitizer in the guinea pig maximization test
and the mouse ear swelling test. There has been one case report of se
nsitization to cyclohexanone itself in a patient using a PVC adhesive composed
of 100% cyclohexanone; patch testing confirmed the sensitizat ion.
Ingestion: Causes gastrointestinal irritation with nausea,
vomiting and diarrhea. May cause liver and kidney damage. May cause central
nervous system depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause collapse,
unconsciousness, coma and possible death due to respiratory failure. May be
harmful if swallowed.
Inhalation: Causes respiratory tract
irritation. May cause liver and kidney damage. Inhalation overexposure may lead
to central nervous system depression, producing effects such as dizziness,
headache, confusion, incoordination, nausea, weakness, and loss of
consciousness. Extreme exposures may cause other CNS effects including death.
Cyclohexanone has caused damage to the liver and kidneys in rabbits ex posed by
inhalation to an airborne concentration of 190 ppm.
Chronic: Prolonged or repeated skin contact may cause
defatting and dermatitis. Prolonged exposure may cause non-specific nervous
system effects. Animal studies indicate that the product may affect the liver
Section 4 - First Aid
Eyes: In case of contact, immediately flush eyes
with plenty of water for at least 15 minutes. Get medical aid.
Skin: In case of contact, immediately flush skin with
plenty of water for at least 15 minutes while removing contaminated clothing and
shoes. Get medical aid immediately. Wash clothing before reuse.
Ingestion: If swallowed, do not induce vomiting unless
directed to do so by medical personnel. Never give anything by mouth to an
unconscious person. Get medical aid.
inhaled, remove to fresh air. If not breathing, give artificial respiration. If
breathing is difficult, give oxygen. Get medical aid.
Physician: Cyclohexanol in urine can be useful in diagnosis.
Section 5 - Fire
Information: As in any fire, wear a self-contained breathing apparatus
in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective
gear. Vapors may form an explosive mixture with air. Use water spray to keep
fire-exposed containers cool. Containers may explode in the heat of a fire.
Flammable liquid and vapor. Vapors are heavier than air and may travel to a
source of ignition and flash back. Vapors can spread along the ground and
collect in low or confined areas.
Water may be ineffective. For large fires, use water spray, fog or
alcohol-resistant foam. Do NOT use straight streams of water. For small fires,
use carbon dioxide, dry chemical, dry sand, or alcohol-resistant foam.
Flash Point: 44 deg C ( 111.20 deg F)
Temperature: 420 deg C ( 788.00 deg F)
Lower:1.10 vol %
Upper: 9.4 vol %
Rating: (estimated) Health: 2; Flammability: 2; Instability: 0
Section 6 -
Accidental Release Measures
Information: Use proper personal protective equipment as indicated in
Spills/Leaks: Absorb spill with inert material
(e.g. vermiculite, sand or earth), then place in suitable container. Avoid
runoff into storm sewers and ditches which lead to waterways. Remove all sources
of ignition. Provide ventilation. Use only non-sparking tools and equipment.
Section 7 - Handling
Handling: Wash thoroughly after handling. Remove
contaminated clothing and wash before reuse. Ground and bond containers when
transferring material. Avoid contact with eyes, skin, and clothing. Empty
containers retain product residue, (liquid and/or vapor), and can be dangerous.
Keep container tightly closed. Do not pressurize, cut, weld, braze, solder,
drill, grind, or expose empty containers to heat, sparks or open flames. Use
only with adequate ventilation. Keep away from heat, sparks and flame. Avoid
breathing vapor or mist.
Storage: Keep away from heat,
sparks, and flame. Keep away from sources of ignition. Store in a tightly closed
container. Store in a cool, dry, well-ventilated area away from incompatible
Section 8 - Exposure
Controls, Personal Protection
Controls: Use explosion-proof ventilation equipment. Facilities storing
or utilizing this material should be equipped with an eyewash facility and a
safety shower. Use adequate general or local exhaust ventilation to keep
airborne concentrations below the permissible exposure limits.
||20 ppm TWA; 50 ppm STEL; skin - potential for cutaneous
||25 ppm TWA; 100 mg/m3 TWA 700 ppm IDLH
||50 ppm TWA; 200 mg/m3
OSHA Vacated PELs:
Cyclohexanone: 25 ppm TWA; 100 mg/m3 TWA
Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent skin
Clothing: Wear appropriate protective clothing to
prevent skin exposure.
Respirators: Follow the OSHA respirator
regulations found in 29 CFR 1910.134 or European Standard EN 149. Always use a
NIOSH or European Standard EN 149 approved respirator when necessary.
Section 9 - Physical
and Chemical Properties
Appearance: clear, colorless to pale yellow
Acetone or peppermint odor
pH: Not applicable.
Pressure: 4.33 mm Hg @ 25 deg C
Vapor Density: 3.4 (air=1)
Evaporation Rate:Not available.
Viscosity: Not available.
Boiling Point: 155 deg C @ 760 mm Hg
Point:-47 deg C
Decomposition Temperature:Not available.
Solubility: Slightly soluble.
Gravity/Density:.9478 @ 20°C
Section 10 -
Stability and Reactivity
Stability: Stable under normal temperatures and pressures.
to Avoid: Ignition sources, excess heat, confined spaces.
Incompatibilities with Other Materials: Strong oxidizing agents,
strong acids, amines, nitric acid, alkalies.
Products: Carbon monoxide, carbon dioxide.
Polymerization: Will not occur.
Section 11 -
CAS# 108-94-1: GW1050000
Draize test, rabbit, eye: 20 mg Severe;
Draize test, rabbit,
eye: 250 ug/24H Severe;
Inhalation, rat: LC50 = 8000 ppm/4H;
LD50 = 1400 mg/kg;
Oral, rat: LD50 = 1620 uL/kg;
Skin, rabbit: LD50 = 1
A3 - Confirmed animal carcinogen with unknown relevance to humans
IARC: IARC Group 3 - not classifiable
Teratogenicity: Animal studies have only shown
harmful effects in the offspring of animals exposed to doses which also produced
significant maternal toxicity.
Reproductive Effects: See actual entry
in RTECS for complete information.
Neurotoxicity: No data available.
Mutagenicity: See actual entry in RTECS for complete information.
Other Studies: No data available.
Section 12 -
Fish: Rainbow trout: LC50 = 90.0 mg/L; 96 Hr.; 320.0 mg/L CaCO3Fish: Rainbow
trout: LC50 = 44.0 mg/L; 96 Hr.; 20.0 mg/L CaCO3Fish: Fathead Minnow: LC50 =
527.0 mg/L; 96 Hr.; Flow-through, 24-26 degrees C,pH7.5Water flea Daphnia:
EC50 = 820.0 mg/L; 48 Hr.; UnspecifiedAlgae: EC50 = 20.0 mg/L; 96 Hr.;
UnspecifiedBacteria: Phytobacterium phosphoreum: EC50 = 18.7 mg/L; 5
minutes; Microtox Test No data available.
chemical is expected to rapidly volatilize based on its low melting and boiling
point. Cyclohexanone is estimated to be highly mobile in soil. In view of its
moderate vapor pressure and low adsorption to soil, it would be expected to
volatilize from surface soil. Although data are lacking, it may also undergo
direct photolysis on the soil surface. Cyclohexanone is readily biodegradable
according to aerobic screening tests and therefore would be expected to
biodegrade in soil.
Physical: No information found.
The bioconcentration factor (BCF) for cyclohexanone can be estimated to be 2.4
based on the log Kow of 0.81 and a recommended regression equation. This BCF
indicates that cyclohexanone will not bioconcentrate in aquatic organisms.
Section 13 - Disposal
Chemical waste generators
must determine whether a discarded chemical is classified as a hazardous waste.
US EPA guidelines for the classification determination are listed in 40 CFR
Parts 261.3. Additionally, waste generators must consult state and local
hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 108-94-1:
waste number U057 (Ignitable waste).
Section 14 -
||No information available.|
Section 15 -
CAS# 108-94-1 is listed on the TSCA
Health & Safety Reporting List
Effective 10/4/82; Sunset 10/4/92
Chemical Test Rules
None of the
chemicals in this product are under a Chemical Test Rule.
None of the chemicals are listed under TSCA Section 12b.
Significant New Use Rule
None of the chemicals in this material have a
SNUR under TSCA.
CERCLA Hazardous Substances and
CAS# 108-94-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the
chemicals in this product have a TPQ.
CAS # 108-94-1:
acute, chronic, flammable.
No chemicals are reportable
under Section 313.
Clean Air Act:
This material does not contain
any hazardous air pollutants. This material does not contain any Class 1 Ozone
depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed
as Hazardous Substances under the CWA. None of the chemicals in this product are
listed as Priority Pollutants under the CWA. None of the chemicals in this
product are listed as Toxic Pollutants under the CWA.
of the chemicals in this product are considered highly hazardous by OSHA.
CAS# 108-94-1 can be found on the following state right to
know lists: California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this product
European Labeling in Accordance with EC
R 20 Harmful by inhalation.
25 Avoid contact with eyes.
WGK (Water Danger/Protection)
Canada - DSL/NDSL
CAS# 108-94-1 is listed on Canada's
Canada - WHMIS
This product has a WHMIS classification
of B3, D2B.
Canadian Ingredient Disclosure List
CAS# 108-94-1 is
listed on the Canadian Ingredient Disclosure List.
CAS# 108-94-1: OEL-AUSTRALIA:TWA 25 ppm (100 mg/m3)
50 ppm (200 mg/m3) OEL-BELGIUM:TWA 25 ppm (100 mg/m3)
VAKIA:TWA 200 mg/m3;STEL 400 mg/m3 OEL-DENMARK:TWA 25 ppm (100
OEL-FINLAND:TWA 50 ppm (200 mg/m3);STEL 75 ppm (250 mg/m3) OEL-FRAN
CE:TWA 25 ppm (100 mg/m3) OEL-GERMANY:TWA 50 ppm (200 mg/m3)
GARY:TWA 100 mg/m3;STEL 200 mg/m3;Skin OEL-JAPAN:TWA 25 ppm (100
3) OEL-THE NETHERLANDS:TWA 50 ppm (200 mg/m3) OEL-THE
A 50 ppm (200 mg/m3) OEL-POLAND:TWA 2 mg/m3 OEL-RUSSIA:TWA 25
EL 10 mg/m3 OEL-SWEDEN:TWA 25 ppm (100 mg/m3);STEL 50 ppm (20
Skin OEL-SWITZERLAND:TWA 25 ppm (100 mg/m3);STEL 50 pp (200 mg/m3)
EL-TURKEY:TWA 50 ppm (200 mg/m3) OEL-UNITED KINGDOM:TWA 25 ppm (100
g/m3);STEL 10 ppm OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGI
TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGI TLV
Section 16 -
MSDS Creation Date:
Revision #5 Date: 8/13/2003
The information above is
believed to be accurate and represents the best information currently available
to us. However, we make no warranty of merchantability or any other warranty,
express or implied, with respect to such information, and we assume no liability
resulting from its use. Users should make their own investigations to determine
the suitability of the information for their particular purposes. In no event
shall Fisher be liable for any claims, losses, or damages of any third party or
for lost profits or any special, indirect, incidental, consequential or
exemplary damages, howsoever arising, even if Fisher has been advised of the
possibility of such damages.