Material Safety Data Sheet
Chromium (VI) Trioxide

ACC# 04940
Section 1 - Chemical Product and Company Identification

MSDS Name: Chromium (VI) Trioxide
Catalog Numbers: S79969, S79969ACS-1, S79969ACS-2, A100-100, A100-212, A100-500, A98-212, A98-500, S79969ACS
Synonyms: Chromic acid; Chromic anhydride; Chromium(VI) oxide; Chromium trioxide.
Company Identification:
              Fisher Scientific
              1 Reagent Lane
              Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887

Section 2 - Composition, Information on Ingredients

CAS# Chemical Name Percent EINECS/ELINCS
1333-82-0 Chromium trioxide >98 215-607-8

Hazard Symbols: T O C N
Risk Phrases: 25 35 43 8 49 50/53

Section 3 - Hazards Identification

EMERGENCY OVERVIEW

Appearance: dark red to purple solid. Danger! Strong oxidizer. Contact with other material may cause a fire. Corrosive. Causes digestive and respiratory tract burns. Causes severe eye and skin burns. Sensitizer. May cause liver and kidney damage. Harmful if swallowed. Corrosive to metal.
Target Organs: Kidneys, liver, lungs, respiratory system, gastrointestinal system, eyes, skin, mucous membranes.


Potential Health Effects
Eye: May cause irreversible eye injury. Contact with eyes may cause severe irritation, and possible eye burns.
Skin: May cause skin sensitization, an allergic reaction, which becomes evident upon re-exposure to this material. May cause irritation with burning pain, itching and redness. May cause deep, penetrating ulcers of the skin. May be absorbed through damaged or abraded skin in harmful amounts. Chronic exposure to water insoluble hexavalent chromium compounds has been shown to be associated with lung cancer and gastrointestinal tract tumors.
Ingestion: Harmful if swallowed. May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. May cause liver and kidney damage.
Inhalation: May cause irritation of the respiratory tract with burning pain in the nose and throat, coughing, wheezing, shortness of breath and pulmonary edema. May cause asthmatic attacks due to allergic sensitization of the respiratory tract.
Chronic: Prolonged or repeated inhalation may cause nosebleeds, nasal congestion, erosion of the teeth, perforation of the nasal septum, chest pain and bronchitis. Prolonged or repeated eye contact may cause conjunctivitis. Prolonged or repeated skin contact may cause sensitization dermatitis and possible destruction and/or ulceration. Chronic ingestion may cause effects similar to those of acute ingestion. Chronic exposure to water insoluble hexavalent chromium compounds has been shown to be associated with lung cancer and gastrointestinal tract tumors.

Section 4 - First Aid Measures


Eyes: Get medical aid immediately. Extensive irrigation with water is required (at least 30 minutes).
Skin: Get medical aid. Wash clothing before reuse. Rinse area with large amounts of water for at least 15 minutes. Destroy contaminated shoes.
Ingestion: If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid immediately.
Inhalation: Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician: Treat symptomatically and supportively.

Section 5 - Fire Fighting Measures


General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Strong oxidizer. Contact with combustible materials may cause a fire. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. Use water spray to keep fire-exposed containers cool. Wear appropriate protective clothing to prevent contact with skin and eyes. Wear a self-contained breathing apparatus (SCBA) to prevent contact with thermal decomposition products. Containers may explode in the heat of a fire. Vapors may be heavier than air. They can spread along the ground and collect in low or confined areas.
Extinguishing Media: Use extinguishing media most appropriate for the surrounding fire. May require flooding with water in order to eliminate hazardous reactions since the materials generate their own oxygen.
Flash Point: 250 deg C ( 482.00 deg F)
Autoignition Temperature: None available.
Explosion Limits, Lower:Not available.
Upper: Not available.
NFPA Rating: (estimated) Health: 3; Flammability: 0; Instability: 1; Special Hazard: OX

Section 6 - Accidental Release Measures


General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Sweep up or absorb material, then place into a suitable clean, dry, closed container for disposal. Avoid generating dusty conditions. Provide ventilation. Do not use combustible materials such as paper towels to clean up spill.

Section 7 - Handling and Storage


Handling: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse. Avoid contact with skin and eyes. Keep container tightly closed. Avoid contact with clothing and other combustible materials. Avoid ingestion and inhalation. Use with adequate ventilation. Discard contaminated shoes.
Storage: Store in a cool, dry, well-ventilated location. Separate from combustible materials, halogens, sulfides, metals. See also NFPA 43A, Code for the Storage of Liquid and Solid Oxidizers.

Section 8 - Exposure Controls, Personal Protection


Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits.
Exposure Limits
Chemical Name ACGIH NIOSH OSHA - Final PELs
Chromium trioxide none listed as CrO3: 0.001 mg/m3 TWA; NIOSH Potential Occupational Carcinogen - see Appendix A; see Appendix C for supplementary exposure limits Potential NIOSH carcinogen; as CrO3: 15 mg/m3 IDLH (no

OSHA Vacated PELs: Chromium trioxide: No OSHA Vacated PELs are listed for this chemical.
Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear a chemical apron. Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear a chemical apron. Wear appropriate protective gloves to prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - Physical and Chemical Properties


Physical State: Solid
Appearance: dark red to purple
Odor: odorless
pH: No information
Vapor Pressure: Not available.
Vapor Density: 3.4
Evaporation Rate:Neglible
Viscosity: No information
Boiling Point: 482 deg F
Freezing/Melting Point:385 deg F
Decomposition Temperature:482 deg F
Solubility: Soluble.
Specific Gravity/Density:2.7 (Water=1)
Molecular Formula:CrO3
Molecular Weight:99.99

Section 10 - Stability and Reactivity


Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Dust generation, excess heat.
Incompatibilities with Other Materials: Metals, reducing agents, combustible materials, halogens, sulfides, pyridine, dimethyl formamide.
Hazardous Decomposition Products: Chromium fumes.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information


RTECS#:
CAS# 1333-82-0: GB6650000
LD50/LC50:
CAS# 1333-82-0:
Oral, mouse: LD50 = 127 mg/kg;
Oral, rat: LD50 = 80 mg/kg;
Carcinogenicity:
CAS# 1333-82-0:
ACGIH: A1 - Confirmed Human Carcinogen (listed as Chromium (VI) compounds- water solubl
California: carcinogen; initial date 2/27/87 (listed as Chromium (VI) compounds).
NIOSH: occupational carcinogen
NTP: Known carcinogen
OSHA: Select carcinogen
IARC: Group 3 carcinogen (listed as Chromium).
Epidemiology: There is an increased incidence of lung cancer in industrial workers exposed to chromium(VI) compounds. Please refer t o IARC volume 23 for a more detailed discussion.
Teratogenicity: Developmental abnormalities of the fetus have been reported in animals by the subcutaneous and intravenous routes.
Reproductive Effects: Post-implantation mortality has been reported in hamsters by the intravenous route.
Neurotoxicity: No information found.
Mutagenicity: See actual entry in RTECS for complete information.
Other Studies: See actual entry in RTECS for complete information.

Section 12 - Ecological Information


Ecotoxicity: No data available. No information available.
Environmental: Chromium trioxide lowers the pH of water.
Physical: No information available.
Other: No information available.

Section 13 - Disposal Considerations

Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: None listed.

Section 14 - Transport Information

US DOT IATA RID/ADR IMO Canada TDG
Shipping Name: CHROMIUM TRIOXIDE, ANHYDROUS CHROMIUM TRIOXIDE ANHYDROUS
Hazard Class: 5.1 5.1(8)(9.2)
UN Number: UN1463 UN1463
Packing Group: II II

Section 15 - Regulatory Information

US FEDERAL

TSCA
CAS# 1333-82-0 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
CAS# 1333-82-0: 6/12b
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA

Section 302 (RQ)
None of the chemicals in this material have an RQ.
Section 302 (TPQ)
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 1333-82-0: acute, chronic.
Section 313
This material contains Chromium trioxide (listed as Chromium), 98%, (CAS# 1333-82-0) which is subject to the reporting requirements of Section 313 of SARA Title III and 40 CFR Part 373.
Clean Air Act:
This material does not contain any hazardous air pollutants. This material does not contain any Class 1 Ozone depletors. This material does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous Substances under the CWA. None of the chemicals in this product are listed as Priority Pollutants under the CWA. None of the chemicals in this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous by OSHA.
STATE
CAS# 1333-82-0 can be found on the following state right to know lists: New Jersey, Florida, Pennsylvania, Massachusetts.
California No Significant Risk Level: None of the chemicals in this product are listed.

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
T O C N
Risk Phrases:
R 25 Toxic if swallowed.
R 35 Causes severe burns.
R 43 May cause sensitization by skin contact.
R 8 Contact with combustible material may cause
fire.
R 49 May cause cancer by inhalation.
R 50/53 Very toxic to aquatic organisms; may cause
long-term adverse effects in the aquatic environment.

Safety Phrases:
S 45 In case of accident or if you feel unwell, seek
medical advice immediately (show the label where
possible).
S 53 Avoid exposure - obtain special instructions
before use.
S 60 This material and/or its container must be
disposed of as hazardous waste.
S 61 Avoid release to the environment. Refer to
special instructions/Safety data sheets.

WGK (Water Danger/Protection)
CAS# 1333-82-0: 3
Canada - DSL/NDSL
CAS# 1333-82-0 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of C, D1B, D2A, E.
Canadian Ingredient Disclosure List
CAS# 1333-82-0 is listed on the Canadian Ingredient Disclosure List.
Exposure Limits
CAS# 1333-82-0: OEL-FINLAND;Carcinogen OEL-FRANCE:TWA 0.05 mg/m3;ST
EL 0.1 mg/m3;Carcinogen OEL-GERMANY;Carcinogen OEL-RUSSIA:STEL 0.01
mg/m3;Skin OEL-SWITZERLAND:TWA 0.05 mg/m3;STEL 0.1 mg/m3 OEL IN BULG
ARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SIN
GAPORE, VIETNAM check ACGI TLV

Section 16 - Additional Information

MSDS Creation Date: 6/04/1998
Revision #6 Date: 4/08/2002

The information above is believed to be accurate and represents the best information currently available to us. However, we make no warranty of merchantability or any other warranty, express or implied, with respect to such information, and we assume no liability resulting from its use. Users should make their own investigations to determine the suitability of the information for their particular purposes. In no event shall Fisher be liable for any claims, losses, or damages of any third party or for lost profits or any special, indirect, incidental, consequential or exemplary damages, howsoever arising, even if Fisher has been advised of the possibility of such damages.