Material
Safety Data Sheet
Acetophenone,
99%
ACC# 00002
|
Section 1 - Chemical Product and Company Identification
|
MSDS Name: Acetophenone, 99%
Catalog Numbers: AC102410000, AC102410010,
AC102410025, AC102410050, AC102412500, A22-500
Synonyms: Methyl phenyl ketone; Phenyl methyl ketone.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
|
Section 2 -
Composition, Information on Ingredients
|
| CAS# |
Chemical
Name |
Percent |
EINECS/ELINCS |
| 98-86-2 |
Acetophenone |
99 |
202-708-7 |
Hazard Symbols: XN
Risk Phrases: 22 36
|
Section 3 -
Hazards Identification
|
EMERGENCY
OVERVIEW
Appearance:
slightly oily liquid. Flash Point: 77 deg C. May be harmful if
swallowed. May cause skin and respiratory tract irritation.
Warning! Causes eye irritation. Combustible liquid
and vapor.
Target Organs: Eyes.
Potential Health
Effects
Eye: May cause transient corneal injury. Causes severe
eye irritation and possible injury. Ocular sensitivity to light has
been reported at 0.002 ppm (0.01 mg/m3 ).
Skin: May cause skin irritation.
Ingestion: May cause gastrointestinal irritation with
nausea, vomiting and diarrhea. May cause central nervous system
depression, characterized by excitement, followed by headache,
dizziness, drowsiness, and nausea. Advanced stages may cause collapse,
unconsciousness, coma and possible death due to respiratory failure.
May be harmful if swallowed.
Inhalation: Inhalation of high concentrations may
cause central nervous system effects characterized by nausea, headache,
dizziness, unconsciousness and coma. Material has a low vapor pressure,
so exposure to vapor is not likely.
Chronic: Prolonged or repeated eye contact may cause
conjunctivitis. Prolonged or repeated skin contact may cause defatting
and dermatitis. Narcotic in high concentrations. Chronic exposure can
cause an acne-like skin rash which is apparently not of the allergic
type.
|
Section 4 -
First Aid Measures
|
Eyes: In case of contact, immediately flush eyes with
plenty of water for at least 15 minutes. Get medical aid.
Skin: In case of contact, flush skin with plenty of
water. Remove contaminated clothing and shoes. Get medical aid if
irritation develops and persists. Wash clothing before reuse.
Ingestion: If swallowed, do not induce vomiting unless
directed to do so by medical personnel. Never give anything by mouth to
an unconscious person. Get medical aid.
Inhalation: If inhaled, remove to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical aid.
Notes to Physician: Exposure indicators: Acetophenone
in expired air and hippuric acid in urine. Treat symptomatically and
supportively.
|
Section 5 -
Fire Fighting Measures
|
General Information: As in any fire, wear a
self-contained breathing apparatus in pressure-demand, MSHA/NIOSH
(approved or equivalent), and full protective gear. During a fire,
irritating and highly toxic gases may be generated by thermal
decomposition or combustion. Use water spray to keep fire-exposed
containers cool. Combustible liquid and vapor.
Extinguishing Media: Use water spray, dry chemical,
carbon dioxide, or appropriate foam.
Flash Point: 77 deg C ( 170.60 deg F)
Autoignition Temperature: 570 deg C ( 1,058.00 deg F)
Explosion Limits, Lower:1.1%
Upper: 6.7%
NFPA Rating: (estimated) Health: 2; Flammability: 2;
Instability: 0
|
Section 6 -
Accidental Release Measures
|
General Information: Use proper personal protective
equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g.
vermiculite, sand or earth), then place in suitable container. Clean up
spills immediately, observing precautions in the Protective Equipment
section. Remove all sources of ignition. Use a spark-proof tool.
Provide ventilation.
|
Section 7 -
Handling and Storage
|
Handling: Wash thoroughly after handling. Remove
contaminated clothing and wash before reuse. Use spark-proof tools and
explosion proof equipment. Avoid contact with eyes, skin, and clothing.
Empty containers retain product residue, (liquid and/or vapor), and can
be dangerous. Avoid ingestion and inhalation. Do not pressurize, cut,
weld, braze, solder, drill, grind, or expose empty containers to heat,
sparks or open flames. Use only with adequate ventilation. Keep away
from heat and flame. Avoid breathing spray or mist.
Storage: Keep away from heat and flame. Keep away from
sources of ignition. Store in a tightly closed container. Store in a
cool, dry, well-ventilated area away from incompatible substances.
|
Section 8 -
Exposure Controls, Personal Protection
|
Engineering Controls: Use process enclosure, local
exhaust ventilation, or other engineering controls to control airborne
levels below recommended exposure limits. Facilities storing or
utilizing this material should be equipped with an eyewash facility and
a safety shower.
Exposure Limits
| Chemical
Name |
ACGIH |
NIOSH |
OSHA
- Final PELs |
| Acetophenone |
10 ppm TWA |
none listed |
none listed |
OSHA Vacated PELs: Acetophenone: No OSHA Vacated PELs
are listed for this chemical.
Personal Protective Equipment
Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent
skin exposure.
Clothing: Wear appropriate protective clothing to
minimize contact with skin.
Respirators: A respiratory protection program that meets OSHA's
29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149
must be followed whenever workplace conditions warrant a respirator's
use.
|
Section 9 -
Physical and Chemical Properties
|
Physical State: Liquid
Appearance: colorless - slightly oily
Odor: orange blossom
pH: Not available.
Vapor Pressure: 0.33 mm Hg @ 20 deg C
Vapor Density: 4.12 (Air=1)
Evaporation Rate:0.06 (diethyl ether=1)
Viscosity: 1.62 cP @ 25 deg C
Boiling Point: 202 deg C @ 760 mm Hg
Freezing/Melting Point:19.6 deg C
Decomposition Temperature:Not available.
Solubility: Insoluble.
Specific Gravity/Density:1.0296 @ 20°C
Molecular Formula:C8H8O
Molecular Weight:120.15
|
Section 10 -
Stability and Reactivity
|
Chemical Stability: Stable under normal temperatures and
pressures.
Conditions to Avoid: Ignition sources, excess heat.
Incompatibilities with Other Materials: Strong oxidizing agents,
strong reducing agents, strong bases, perchloric acid, aldehydes,
nitric acid + hydrogen peroxide.
Hazardous Decomposition Products: Carbon monoxide, carbon
dioxide.
Hazardous Polymerization: Has not been reported.
|
Section 11 -
Toxicological Information
|
RTECS#:
CAS# 98-86-2: AM5250000
LD50/LC50:
CAS# 98-86-2:
Dermal, guinea pig: LD50 = >20 mL/kg;
Draize test, rabbit, eye: 750 ug Severe;
Oral, mouse: LD50 = 740 mg/kg;
Oral, rat: LD50 = 815 mg/kg;
Skin, rabbit: LD50 = 15900 uL/kg;
Carcinogenicity:
CAS# 98-86-2: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: No information available.
Teratogenicity: No information available.
Reproductive Effects: No information available.
Neurotoxicity: No information available.
Mutagenicity: Cytogenetic Analysis: Hamster, Lung = 600 mg/L.
Other Studies: Standard Draize Test: Administration into the eye
(rabbit) = 750 ug/24H (Severe). Open Irritation Test: Administrat ion
onto the skin (rabbit) = 515 mg (Mild).
|
Section 12 -
Ecological Information
|
Ecotoxicity: Fish: Fathead Minnow: LC50 = 196 mg/L; 96 Hr;
Flow-through at 24.6 C (pH 7.83)Bacteria: Phytobacterium phosphoreum:
EC50 = 15.5 mg/L; 5,15,30 min; Microtox test at 15 C If released to
soil, microbial degradation is likely to be the major degradation
pathway. It is expected to be moderately to highly mobile in soil and
may evaporate from dry soil surfaces. Biodegradation and volatilization
are expected to be the major loss processes in water. The estimated
biodegradation half-lives in groundwater, river water and lake water
samples were 32 days, 8 days and 4.5 days, respectively.
Environmental: Hydrolysis, oxidation and adsorption to suspended
particles and sediments and bioconcentration in aquatic organisms are
not likely to be important fate processes. Oxidation by hydroxyl
radicals in air has an estimated half-life of 2.2 days. Other oxidants
(eg, ozone) and photolysis do not appear to be important loss mechanism
of this compound in air. Wet deposition may be important for the
removal of atmospheric acetophenone.
Physical: No information available.
Other: No information available.
|
Section 13 -
Disposal Considerations
|
Chemical
waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the
classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous
waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 98-86-2: waste number U004.
|
Section 14 -
Transport Information
|
|
US
DOT |
IATA |
RID/ADR |
IMO |
Canada
TDG |
| Shipping Name: |
No information available. |
|
|
|
No information available. |
| Hazard Class: |
|
|
|
|
|
| UN Number: |
|
|
|
|
|
| Packing Group: |
|
|
|
|
|
|
Section 15 -
Regulatory Information
|
US
FEDERAL
TSCA
CAS# 98-86-2 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
CERCLA Hazardous Substances and corresponding RQs
CAS# 98-86-2: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 98-86-2: acute, flammable.
Section 313
This material contains Acetophenone (CAS# 98-86-2, 99%),which is
subject to the reporting requirements of Section 313 of SARA Title III
and 40 CFR Part 373.
Clean Air Act:
CAS# 98-86-2 is listed as a hazardous air pollutant (HAP). This
material does not contain any Class 1 Ozone depletors. This material
does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous
Substances under the CWA. None of the chemicals in this product are
listed as Priority Pollutants under the CWA. None of the chemicals in
this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous
by OSHA.
STATE
CAS# 98-86-2 can be found on the following state right to know lists:
New Jersey, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this
product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XN
Risk Phrases:
R 22 Harmful if swallowed.
R 36 Irritating to eyes.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
WGK (Water Danger/Protection)
CAS# 98-86-2: 1
Canada - DSL/NDSL
CAS# 98-86-2 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B3, D2B.
Canadian Ingredient Disclosure List
CAS# 98-86-2 is listed on the Canadian Ingredient Disclosure List.
Exposure Limits
CAS# 98-86-2: OEL-HUNGARY:TWA 15 mg/m3;STEL 30 mg/m3;Skin OEL-RUSSI
A:STEL 5 mg/m3;Skin
|
Section 16 -
Additional Information
|
MSDS
Creation Date: 5/25/1999
Revision #4 Date: 12/03/2002
The information above is believed to be accurate and represents the
best information currently available to us. However, we make no
warranty of merchantability or any other warranty, express or implied,
with respect to such information, and we assume no liability resulting
from its use. Users should make their own investigations to determine
the suitability of the information for their particular purposes. In no
event shall Fisher be liable for any claims, losses, or damages of any
third party or for lost profits or any special, indirect, incidental,
consequential or exemplary damages, howsoever arising, even if Fisher
has been advised of the possibility of such damages.