Material
Safety Data Sheet
Acetone
ACC# 00140
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Section 1 - Chemical Product and Company Identification
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MSDS Name: Acetone
Catalog Numbers: AC167640000, AC167640025,
AC167645000, AC176800000, AC176800010, AC176800025, AC176805000,
AC177170000, AC177170010, AC177170025, AC177170250, AC177179090,
AC268310000, AC268310010, AC268310025, AC268310040, AC326570000,
AC326570010, AC326570025, AC326700000, AC326700010, AC326700025,
AC326740000, AC326740010, AC326740025, AC326800000, AC326800010,
AC326801000, AC326802500, AC327840000, AC327840010, AC327840040,
AC400100000, AC400100010, AC400100025, AC400100040, AC400105000,
AC423240000, AC423240010, AC423240040, AC423245000, AC611010040,
A19RS115, S70090, S70091, S70091-1, A11-1, A11-20, A11-200, A11-4,
A11S-4, A16F-1GAL, A16P-4, A16P1GAL, A16S-20, A16S-4, A18-1, A18-20,
A18-200, A18-4, A18-500, A18CU-1300, A18FB115, A18FB19, A18FB200,
A18FB50, A18J500, A18P-4, A18POP19, A18POP200, A18POP50, A18POPB19,
A18POPB200, A18POPB50, A18RB-115, A18RB-19, A18RB-200, A18RB-50,
A18RS-115, A18RS-200, A18RS-28, A18RS-50, A18S-4, A18SK-4, A18SS-115,
A18SS-200, A18SS-28, A18SS-50, A18SS1350, A18SS19, A19-1, A19-4, A40-4,
A404LC, A920, A9200, A928-4, A929-1, A929-4, A929J1, A929J4, A929POP19,
A929POP200, A929POP50, A929RS-19, A929RS-200, A929RS-50, A929SS-115,
A929SS-200, A929SS-28, A929SS-50, A929SS19, A94, A946-4, A9464LC,
A946FB19, A946FB200, A946FB50, A946POPB19, A946POPB200, A946POPB50,
A946RB115, A946RB19, A946RB200, A946RB50, A949-1, A949-4, A9491LC,
A949CU50, A949J1, A949J4, A949N119, A949N219, A949NB219, A949POP19,
A949POP200, A949POP50, A949POPN19, A949RS-115, A949RS-28, A949RS-50,
A949SK-1, A949SK-4, A949SK4LC, A949SS-115, A949SS-200, A949SS-28,
A949SS-50, A949SS19, BP24011, BP240320, BP24034, BP2403500, BP24044,
BP2404SK1, BP2404SK4, HC3001GAL, JONA18, NC9060899, NC9096457,
NC9120377, NC9173151, NC9475452, NC9614315, NC9905244, PS03488, PS03489
Synonyms: Dimethylketone; 2-Propanone.
Company Identification:
Fisher Scientific
1 Reagent Lane
Fair Lawn, NJ 07410
For information, call: 201-796-7100
Emergency Number: 201-796-7100
For CHEMTREC assistance, call: 800-424-9300
For International CHEMTREC assistance, call: 703-527-3887
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Section 2 -
Composition, Information on Ingredients
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| CAS# |
Chemical
Name |
Percent |
EINECS/ELINCS |
| 67-64-1 |
Acetone |
>99 |
200-662-2 |
Hazard Symbols: XI F
Risk Phrases: 11 36
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Section 3 -
Hazards Identification
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EMERGENCY
OVERVIEW
Appearance:
clear, colorless liquid. Flash Point: -20 deg C. Causes eye irritation.
Breathing vapors may cause drowsiness and dizziness. Prolonged or
repeated contact may dry the skin and cause irritation. Danger!
Extremely flammable liquid and vapor. Vapor may cause flash fire.
Aspiration hazard if swallowed. Can enter lungs and cause damage.
Causes respiratory tract irritation.
Target Organs: Central nervous system, respiratory
system, eyes, skin.
Potential Health
Effects
Eye: Produces irritation, characterized by a burning
sensation, redness, tearing, inflammation, and possible corneal injury.
Vapors cause eye irritation.
Skin: May be absorbed through the skin. Repeated or
prolonged exposure may cause drying and cracking of the skin.
Ingestion: May cause irritation of the digestive
tract. May cause central nervous system depression, characterized by
excitement, followed by headache, dizziness, drowsiness, and nausea.
Advanced stages may cause collapse, unconsciousness, coma and possible
death due to respiratory failure. Aspiration of material into the lungs
may cause chemical pneumonitis, which may be fatal.
Inhalation: Inhalation of high concentrations may
cause central nervous system effects characterized by nausea, headache,
dizziness, unconsciousness and coma. Causes respiratory tract
irritation. May cause motor incoordination and speech abnormalities.
Chronic: Prolonged or repeated skin contact may cause
dermatitis. Chronic inhalation may cause effects similar to those of
acute inhalation. Matsushita et al. exposed human volunteers 6
hours/day for 6 days at 5 00 ppm and found hematologic changes
including significantly increased leukocyte and eosinophil counts and
decreased neutrophil phagocytic a ctivity.
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Section 4 -
First Aid Measures
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Eyes: In case of contact, immediately flush eyes with
plenty of water for at least 15 minutes. Get medical aid.
Skin: In case of contact, flush skin with plenty of
water. Remove contaminated clothing and shoes. Get medical aid if
irritation develops and persists. Wash clothing before reuse.
Ingestion: Potential for aspiration if swallowed. Get
medical aid immediately. Do not induce vomiting unless directed to do
so by medical personnel. Never give anything by mouth to an unconscious
person.
Inhalation: If inhaled, remove to fresh air. If not
breathing, give artificial respiration. If breathing is difficult, give
oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and
supportively.
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Section 5 -
Fire Fighting Measures
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General Information: Containers can build up pressure
if exposed to heat and/or fire. As in any fire, wear a self-contained
breathing apparatus in pressure-demand, MSHA/NIOSH (approved or
equivalent), and full protective gear. During a fire, irritating and
highly toxic gases may be generated by thermal decomposition or
combustion. Use water spray to keep fire-exposed containers cool.
Extremely flammable liquid and vapor. Vapor may cause flash fire.
Vapors are heavier than air and may travel to a source of ignition and
flash back. Vapors can spread along the ground and collect in low or
confined areas.
Extinguishing Media: Use dry chemical, carbon dioxide,
or appropriate foam. Water may be ineffective because it will not cool
material below its flash point.
Flash Point: -20 deg C ( -4.00 deg F)
Autoignition Temperature: 465 deg C ( 869.00 deg F)
Explosion Limits, Lower:2.5%
Upper: 12.8%
NFPA Rating: (estimated) Health: 1; Flammability: 3;
Instability: 0
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Section 6 -
Accidental Release Measures
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General Information: Use proper personal protective
equipment as indicated in Section 8.
Spills/Leaks: Absorb spill with inert material (e.g.
vermiculite, sand or earth), then place in suitable container. Avoid
runoff into storm sewers and ditches which lead to waterways. Wear
appropriate protective clothing to minimize contact with skin. Remove
all sources of ignition. Provide ventilation. A vapor suppressing foam
may be used to reduce vapors. Water spray may reduce vapor but may not
prevent ignition in closed spaces. Use only non-sparking tools and
equipment.
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Section 7 -
Handling and Storage
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Handling: Wash thoroughly after handling. Remove
contaminated clothing and wash before reuse. Ground and bond containers
when transferring material. Avoid contact with eyes, skin, and
clothing. Empty containers retain product residue, (liquid and/or
vapor), and can be dangerous. Keep container tightly closed. Do not
pressurize, cut, weld, braze, solder, drill, grind, or expose empty
containers to heat, sparks or open flames. Use only with adequate
ventilation. Keep away from heat, sparks and flame. Avoid breathing
vapor.
Storage: Keep away from sources of ignition. Store in
a tightly closed container. Store in a cool, dry, well-ventilated area
away from incompatible substances. Flammables-area.
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Section 8 -
Exposure Controls, Personal Protection
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Engineering Controls: Facilities storing or utilizing
this material should be equipped with an eyewash facility and a safety
shower. Use adequate general or local exhaust ventilation to keep
airborne concentrations below the permissible exposure limits.
Ventilation fans and other electrical service must be non-sparking and
have an explosion-proof design.
Exposure Limits
| Chemical
Name |
ACGIH |
NIOSH |
OSHA
- Final PELs |
| Acetone |
500 ppm TWA; 750 ppm STEL |
250 ppm TWA; 590 mg/m3 TWA 2500
ppm IDLH |
1000 ppm TWA; 2400 mg/m3 TWA |
OSHA Vacated PELs: Acetone: 750 ppm TWA; 1800 mg/m3
TWA
Personal Protective Equipment
Eyes: Wear chemical goggles.
Skin: Wear appropriate protective gloves to prevent
skin exposure.
Clothing: Wear appropriate protective clothing to
prevent skin exposure.
Respirators: Follow the OSHA respirator regulations found in 29
CFR 1910.134 or European Standard EN 149. Always use a NIOSH or
European Standard EN 149 approved respirator when necessary.
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Section 9 -
Physical and Chemical Properties
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Physical State: Liquid
Appearance: clear, colorless
Odor: sweetish odor
pH: 7
Vapor Pressure: 231 mm Hg @ 25 deg C
Vapor Density: 2.0 (Air=1)
Evaporation Rate:5.6 (n-Butyl acetate=1)
Viscosity: 0.32 cps @ 20 deg C
Boiling Point: 56 deg C
Freezing/Melting Point:-94 deg C
Decomposition Temperature:Not available.
Solubility: Soluble.
Specific Gravity/Density:0.788 @ 25°C
Molecular Formula:C3H6O
Molecular Weight:58.08
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Section 10 -
Stability and Reactivity
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Chemical Stability: Stable at room temperature in closed
containers under normal storage and handling conditions.
Conditions to Avoid: High temperatures, ignition sources,
confined spaces.
Incompatibilities with Other Materials: Strong oxidizing agents,
strong reducing agents, strong bases, nitric acid, hexachloromelamine,
sulfur dichloride, potassium tert-butoxide, chloroform + alkali,
sulfuric acid + nitric acid.
Hazardous Decomposition Products: Carbon monoxide, carbon
dioxide.
Hazardous Polymerization: Will not occur.
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Section 11 -
Toxicological Information
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RTECS#:
CAS# 67-64-1: AL3150000
LD50/LC50:
CAS# 67-64-1:
Dermal, guinea pig: LD50 = >9400 uL/kg;
Draize test, rabbit, eye: 20 mg Severe;
Draize test, rabbit, eye: 20 mg/24H Moderate;
Draize test, rabbit, eye: 10 uL Mild;
Draize test, rabbit, skin: 500 mg/24H Mild;
Inhalation, mouse: LC50 = 44 gm/m3/4H;
Inhalation, rat: LC50 = 50100 mg/m3/8H;
Oral, mouse: LD50 = 3 gm/kg;
Oral, rabbit: LD50 = 5340 mg/kg;
Oral, rat: LD50 = 5800 mg/kg;
Carcinogenicity:
CAS# 67-64-1: Not listed by ACGIH, IARC, NIOSH, NTP, or OSHA.
Epidemiology: No information available.
Teratogenicity: No information available.
Reproductive Effects: During the Stewart et al. study, four
adult female volunteers were exposed 7.5 hours to acetone vapor at a
nominal concentration of 1000 ppm. Three of the four women experienced
premature menstrual periods which were attributed to the acetone
exposure.
Neurotoxicity: No information available.
Mutagenicity: Sex chromosome loss and nondisjunction(Yeast -
Saccharomyces cerevisiae) = 47600 ppm; Cytogenetic analysis(Rodent -
hamster Fibroblast)= 40 gm/L.
Other Studies: Standard Draize Test: Administration onto the
skin (human) = 500 mg/7days (Mild). Standard Draize Test: Administrat
ion onto the skin (rabbit) = 500 mg/24H (Mild). Standard D raize Test(
Eye, Rabbit) = 20 mg; Severe.
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Section 12 -
Ecological Information
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Ecotoxicity: Fish: Rainbow trout: 5540 mg/l; 96-hr; LC50Fish:
Bluegill/Sunfish: 8300 mg/l; 96-hr; LC50 No data available.
Environmental: Volatilizes, leeches, and biodegrades when
released to soil. TERRESTRIAL FATE: If released on soil, acetone will
both volatilize and leach into the ground. Acetone readily biodegrades
and there is evidence suggesting that it biodegrades fairly rapidly in
soils. AQUATIC FATE: If released into water, acetone will probably
biodegrade. It is readily biodegradable in screening tests, although
data from natural water are lacking. It will also be lost due to
volatilization (estimated half-life 20 hr from a model river).
Adsorption to sediment should not be significant.
Physical: ATMOSPHERIC FATE: In the atmosphere, acetone will be
lost by photolysis and reaction with photochemically produced hydroxyl
radicals. Half-life estimates from these combined processes are 79 and
13 days in January and June, respectively, for an overall annual
average of 22 days. Therefore considerable dispersion should occur.
Being miscible in water, wash out by rain should be an important
removal process. This process has been confirmed around Lake Shinsei-ko
in Japan. There acetone was found in the air and rain as well as the
lake.
Other: No information available.
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Section 13 -
Disposal Considerations
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Chemical
waste generators must determine whether a discarded chemical is
classified as a hazardous waste. US EPA guidelines for the
classification determination are listed in 40 CFR Parts 261.3.
Additionally, waste generators must consult state and local hazardous
waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed.
RCRA U-Series: CAS# 67-64-1: waste number U002 (Ignitable
waste).
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Section 14 -
Transport Information
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US
DOT |
IATA |
RID/ADR |
IMO |
Canada
TDG |
| Shipping Name: |
ACETONE |
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ACETONE |
| Hazard Class: |
3 |
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3 |
| UN Number: |
UN1090 |
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UN1090 |
| Packing Group: |
II |
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II |
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Section 15 -
Regulatory Information
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US
FEDERAL
TSCA
CAS# 67-64-1 is listed on the TSCA inventory.
Health & Safety Reporting List
None of the chemicals are on the Health & Safety Reporting List.
Chemical Test Rules
None of the chemicals in this product are under a Chemical Test Rule.
Section 12b
None of the chemicals are listed under TSCA Section 12b.
TSCA Significant New Use Rule
None of the chemicals in this material have a SNUR under TSCA.
SARA
CERCLA Hazardous Substances and corresponding RQs
CAS# 67-64-1: 5000 lb final RQ; 2270 kg final RQ
SARA Section 302 Extremely Hazardous Substances
None of the chemicals in this product have a TPQ.
SARA Codes
CAS # 67-64-1: acute, flammable.
Section 313
No chemicals are reportable under Section 313.
Clean Air Act:
This material does not contain any hazardous air pollutants. This
material does not contain any Class 1 Ozone depletors. This material
does not contain any Class 2 Ozone depletors.
Clean Water Act:
None of the chemicals in this product are listed as Hazardous
Substances under the CWA. None of the chemicals in this product are
listed as Priority Pollutants under the CWA. None of the chemicals in
this product are listed as Toxic Pollutants under the CWA.
OSHA:
None of the chemicals in this product are considered highly hazardous
by OSHA.
STATE
CAS# 67-64-1 can be found on the following state right to know lists:
California, New Jersey, Pennsylvania, Minnesota, Massachusetts.
California No Significant Risk Level: None of the chemicals in this
product are listed.
European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols:
XI F
Risk Phrases:
R 11 Highly flammable.
R 36 Irritating to eyes.
R 66 Repeated exposure may cause skin dryness or
cracking.
R 67 Vapours may cause drowsiness and dizziness.
Safety Phrases:
S 16 Keep away from sources of ignition - No
smoking.
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 9 Keep container in a well-ventilated place.
WGK (Water Danger/Protection)
CAS# 67-64-1: 0
Canada - DSL/NDSL
CAS# 67-64-1 is listed on Canada's DSL List.
Canada - WHMIS
This product has a WHMIS classification of B2, D2B.
Canadian Ingredient Disclosure List
CAS# 67-64-1 is listed on the Canadian Ingredient Disclosure List.
Exposure Limits
CAS# 67-64-1: OEL-AUSTRALIA:TWA 500 ppm (1185 mg/m3);STEL 1000 ppm
OEL-AUSTRIA:TWA 750 ppm (1780 mg/m3) OEL-BELGIUM:TWA 750 ppm (1780 mg
/m3);STEL 1000 pp OEL-CZECHOSLOVAKIA:TWA 800 mg/m3;STEL 4000 mg/m3 O
EL-DENMARK:TWA 250 ppm (600 mg/m3) OEL-FINLAND:TWA 500 ppm (1200 mg/m
3);STEL 625 ppm (1500 mg/m3) OEL-FRANCE:TWA 750 ppm (1800 mg/m3) OEL
-GERMANY:TWA 1000 ppm (2400 mg/m3) OEL-HUNGARY:TWA 600 mg/m3;STEL 120
0 mg/m3 OEL-INDIA:TWA 750 ppm (1780 mg/m3);STEL 1000 ppm (2375 mg/m3)
OEL-JAPAN:TWA 200 ppm (470 mg/m3) OEL-THE NETHERLANDS:TWA 750 ppm (
1780 mg/m3) JAN9 OEL-THE PHILIPPINES:TWA 1000 ppm (2400 mg/m3) OEL-P
OLAND:TWA 200 mg/m3 OEL-RUSSIA:TWA 200 ppm;STEL 200 mg/m3 OEL-SWEDEN
:TWA 250 ppm (600 mg/m3);STEL 500 ppm (1200 mg/m3) OEL-SWITZERLAND:TW
A 750 ppm (1780 mg/m3) OEL-TURKEY:TWA 1000 ppm (2400 mg/m3) OEL-UNIT
ED KINGDOM:TWA 750 ppm (1810 mg/m3);STEL 1250 ppm OEL IN BULGARIA, CO
LOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE,
VIETNAM check ACGI TLV
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Section 16 -
Additional Information
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MSDS
Creation Date: 7/26/1999
Revision #15 Date: 3/05/2004
The information above is believed to be accurate and represents the
best information currently available to us. However, we make no
warranty of merchantability or any other warranty, express or implied,
with respect to such information, and we assume no liability resulting
from its use. Users should make their own investigations to determine
the suitability of the information for their particular purposes. In no
event shall Fisher be liable for any claims, losses, or damages of any
third party or for lost profits or any special, indirect, incidental,
consequential or exemplary damages, howsoever arising, even if Fisher
has been advised of the possibility of such damages.